Paradoxical reaction to treatment in 2 patients with severe acute paracoccidioidomycosis: a previously unreported complication and its management with corticosteroids.

Gryschek, Ronaldo C B; Pereira, Ricardo M; Kono, Adriana; Patzina, Rosely A; Tresoldi, Antonia T; Shikanai-Yasuda, Maria A; Benard, Gil · Clin Infect Dis · 2010

case_series · Level IV

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Abstract

Paradoxical reactions have never been described in patients with paracoccidioidomycosis or other deep endemic mycoses out of the context of human immunodeficiency virus infection. We describe 2 patients with an acute form of paracoccidioidomycosis who presented with a worsening of their clinical manifestations while on appropriate antifungal treatment. These manifestations were severe and required adjunct corticosteroid therapy.

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