Capsaicin pretreatment does not inhibit allergen-induced airway microvascular leakage in guinea pig.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 2039076.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have studied the effects of tachykinin-depletion on airway microvascular leakage induced by allergen challenge in ovalbumin-sensitised guinea pigs. Tachykinin-depletion was obtained by capsaicin pretreatment 1 week before inhaled allergen challenge. Capsaicin pretreatment did not change airway microvascular permeability induced by allergen challenge. Thus, sensory neuropeptides may not be important in allergen-induced acute airway microvascular leakage in guinea pig in vivo.
Medical subject headings
- Capillary Permeability
- Capsaicin
- Lung