Invasive fungal disease in autosomal-dominant hyper-IgE syndrome.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 20392475.
- Also identified by DOI 10.1016/j.jaci.2010.01.047 and PMC identifier 2879472.
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Abstract
We demonstrate that autosomal-dominant <i>STAT3</i>-deficient hyper-IgE syndrome confers late-onset susceptibility to molds, especially <i>Aspergillus</i>, despite preserved myeloid functions, in association with previous parenchymal lung damage (bronchiectasis/pneumatoceles). This suggests a critical role for non-hematopoietic processes in innate antifungal immunity in AD-HIES.
Medical subject headings
- Aspergillus
- Immunoglobulin E
- Invasive Pulmonary Aspergillosis
- Job Syndrome
- STAT3 Transcription Factor