Ozone activates pulmonary dendritic cells and promotes allergic sensitization through a Toll-like receptor 4-dependent mechanism.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 20394980.
- Also identified by DOI 10.1016/j.jaci.2010.03.001 and PMC identifier 2866779.
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Abstract
Human exposure to ozone is associated with increased prevalence of allergic asthma. Here, we demonstrate that ozone increases levels of activated dendritic cells in thoracic lymph nodes and promotes allergic sensitization through a TLR4-dependent pathway.
Medical subject headings
- Air Pollutants
- Dendritic Cells
- Lung
- Ozone
- Respiratory Hypersensitivity
- Toll-Like Receptor 4