Ricin toxin hits a retrograde roadblock.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20403318.
- Also identified by DOI 10.1016/j.cell.2010.03.044.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To inhibit protein synthesis and induce cell death, plant ricin toxin and bacterial Shiga toxins enter the cell through the endocytic and retrograde secretory pathways. Stechmann et al. (2010) now identify two small-molecule inhibitors that selectively block endosome-to-Golgi retrieval of ricin and Shiga toxins and protect mice from ricin's deadly effects.