Sealing of submicrometer wells by a shear-driven lipid bilayer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20405904.
- Also identified by DOI 10.1021/nl100779k.
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Abstract
A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.
Medical subject headings
- Lipid Bilayers
- Microfluidics
- Nanostructures
- Nanotechnology