Continuous venovenous hemofiltration in the management of acute decompensation in inborn errors of metabolism.

Thompson, G N; Butt, W W; Shann, F A; Kirby, D M; Henning, R D; Howells, D W; Osborne, A · J Pediatr · 1991

case_series · Level IV

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Abstract

Continuous venovenous hemofiltration was used to treat two neonates, one with maple syrup urine disease and the other with an inborn error of long-chain fatty acid oxidation. The latter infant had hypoglycemia, hyperammonemia and lactic acidosis. In both cases, acceptable biochemical control was achieved within 8 hours. This therapy offers the potential to overcome acute crises rapidly in a wide range of inborn errors of intermediary metabolism.

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