Drug resistance, epigenetics, and tumor cell heterogeneity.
Level V
Where this comes from
- Record sourced from PubMed, PMID 20410528.
- Also identified by DOI 10.1126/scitranslmed.3001056.
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Abstract
The resistance of cancer cells to various therapeutic agents and modalities is a crucial issue in clinical oncology. A recent Cell paper highlights how changes at the chromatin level control drug sensitivity and provides insight into more effective strategies for treating cancer with combination therapies.
Medical subject headings
- Drug Resistance, Neoplasm
- Epigenesis, Genetic
- Genetic Heterogeneity
- Neoplasms