A BRCA1 promoter variant (rs11655505) and breast cancer risk.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 20413709.
- Also identified by DOI 10.1136/jmg.2009.073544.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk. We genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies. No evidence for an association between rs11655505 and breast cancer risk was found. Our study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.
Medical subject headings
- Breast Neoplasms
- Genes, BRCA1