Diabetes forum: Extreme makeover of pancreatic alpha-cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20414295.
- Also identified by DOI 10.1038/4641132a and PMC identifier PMC4617625.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Most insulin-secreting pancreatic β-cells are irreplaceably lost in type 1 diabetes. In a mouse model, pancreatic α-cells seem to sacrifice their identity to replenish the low stock of β-cells. Two experts discuss what this means for understanding the basic cell biology involved and its relevance to treating diabetes.