Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20415572.
- Also identified by DOI 10.1086/652655.
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Abstract
Immunosuppressed patients receiving oseltamivir for 2009 novel H1N1 influenza A infection may develop drug resistance, leading to treatment failure. Intravenous zanamivir was administered on a compassionate-use basis to a profoundly immunosuppressed pediatric patient with severe oseltamivir-resistant novel H1N1 pneumonia. The regimen was well tolerated and was associated with a decrease in viral burden.
Medical subject headings
- Antiviral Agents
- Drug Resistance, Viral
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Oseltamivir
- Zanamivir