Peginterferon alpha-2b and acute allograft failure in a heart transplant recipient.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20417802.
- Also identified by DOI 10.1016/j.athoracsur.2009.09.084.
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Abstract
Reports of heart transplant recipients with hepatitis C viral infection treated with peginterferon alpha-2b and ribavirin are very rare. We report a fatal case of acute allograft failure and hepatitis C viral infection in a 50-year-old orthotopic heart transplant recipient. At autopsy, the patient was found to have patent coronary arteries, diffuse severe fatty degeneration of heart myocytes, and no evidence of cellular or humoral rejection, confirming this as a fatal case of cardiotoxicity from peginterferon alpha-2b.
Medical subject headings
- Graft Rejection
- Heart Transplantation
- Hepatitis C, Chronic
- Interferon-alpha
- Polyethylene Glycols