CGHnormaliter: a Bioconductor package for normalization of array CGH data with many CNAs.
basic_science · Level V
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- Record sourced from PubMed, PMID 20418341.
- Also identified by DOI 10.1093/bioinformatics/btq155.
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Abstract
CGHnormaliter is a package for normalization of array comparative genomic hybridization (aCGH) data. It uses an iterative procedure that effectively eliminates the influence of imbalanced copy numbers. This leads to a more reliable assessment of copy number alterations (CNAs). CGHnormaliter is integrated in the Bioconductor environment allowing a smooth link to visualization tools and further data analysis. The CGHnormaliter package is implemented in R and under GPL 3.0 license available at Bioconductor: http://www.bioconductor.org heringa@few.vu.nl
Medical subject headings
- Comparative Genomic Hybridization
- Oligonucleotide Array Sequence Analysis
- Software