ACTH protects against glucocorticoid-induced osteonecrosis of bone.
Level V
Where this comes from
- Record sourced from PubMed, PMID 20421485.
- Also identified by DOI 10.1073/pnas.0912176107 and PMC identifier 2889316.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.
Medical subject headings
- Adrenocorticotropic Hormone
- Femur
- Glucocorticoids
- Osteonecrosis
- Protective Agents