A substantial transmission bottleneck among newly and recently HIV-1-infected injection drug users in St Petersburg, Russia.
Where this comes from
- Record sourced from PubMed, PMID 20423223.
- Also identified by DOI 10.1086/652702.
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Abstract
There are limited data on the genetic complexity of human immunodeficiency virus type 1 (HIV-1) after transmission among a cohort of injection drug users (IDUs). We used single-genome amplification of HIV-1 env to determine the genotypic characteristics of virus among IDUs with acute infection in St Petersburg, Russia. Our results indicate that a single variant was transmitted in a majority of cases (9 of 13 participants), which is analogous to what is observed in sexual transmission. These data are most consistent with a genetic bottleneck during transmission by injection drug use that is due to a small inoculum, which most often results in the transmission of a low-complexity viral population.
Medical subject headings
- Drug Users
- HIV Infections
- HIV-1
- Substance Abuse, Intravenous