Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy.
case_report · Level V
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- Record sourced from PubMed, PMID 2042950.
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Abstract
A 9-year-old, blind boy with severe mental retardation with a chronic sleep/wake disturbance had a circadian rhythm of 24.75 hours and an internal desynchronization of the endogenous rhythms. Treatment with oral melatonin given at 6 PM induced a regular sleep/wake pattern. Melatonin, in this patient, convincingly entrained the endogenous rhythm to the appropriate chronological 24-hour day.
Medical subject headings
- Blindness
- Intellectual Disability
- Melatonin
- Sleep
- Wakefulness