The riddle of the sphinx redux.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20431574.
- Also identified by DOI 10.1038/ki.2010.72 and PMC identifier 3644478.
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Abstract
Understanding the mechanisms of glucocorticoid-mediated inhibition of inflammation has been challenging. This is particularly true with regard to the development of drugs that mimic the anti-inflammatory benefits of steroids while avoiding the untoward metabolic effects. Förster et al. report that the inhibition of stress-induced mesangial-cell apoptosis by dexamethasone is mediated by sphingosine-1-phosphate. These findings identify alternative pathways whereby the anti-inflammatory mechanisms of glucocorticoids can be probed.
Medical subject headings
- Anti-Inflammatory Agents
- Glucocorticoids
- Inflammation