Tetherin: holding on and letting go.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20434978.
- Also identified by DOI 10.1016/j.cell.2010.04.022.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mammalian cells are equipped with so-called "restriction factors" that suppress virus replication and help to prevent virus transmission from one species to another. This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such as Vpu and Nef, that antagonize tetherin's action.
Medical subject headings
- Antigens, CD
- HIV-1
- Membrane Glycoproteins