The apoptosome at high resolution.
basic_science · Level V
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- Record sourced from PubMed, PMID 20434981.
- Also identified by DOI 10.1016/j.cell.2010.04.015 and PMC identifier 2936229.
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Abstract
The mechanism by which the apoptosome activates caspases during apoptosis has been controversial. Qi et al. (2010) now present a crystal structure of a funnel-shaped octameric apoptosome complex from the nematode Caenorhabditis elegans that challenges currently held assumptions about the human apoptosome structure.