Guiding endosomal maturation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20434982.
- Also identified by DOI 10.1016/j.cell.2010.04.013.
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Abstract
In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).