Synergistic induction of profibrotic PAI-1 by TGF-β and radiation depends on p53.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20435362.
- Also identified by DOI 10.1016/j.radonc.2010.04.002.
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Abstract
Radiation-induced fibrosis is a severe side effect of radiotherapy. TGF-β and radiation synergistically induce expression of the profibrotic PAI-1 gene and this cooperation potentially involves p53. Here, we demonstrate that p53 is both indispensable and sufficient for the radiation effect inducing synergistic activation of PAI-1 by radiation and TGF-β.
Medical subject headings
- Neoplasms
- Plasminogen Activator Inhibitor 1
- Radiation Tolerance
- Radiotherapy
- Transforming Growth Factor beta1
- Tumor Suppressor Protein p53