Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20437566.
- Also identified by DOI 10.1002/ana.21949.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
P2X3 purinoreceptors expressed in mammalian sensory neurons play a key role in several processes, including pain perception. From the venom of the Central Asian spider Geolycosa sp., we have isolated a novel peptide, named purotoxin-1 (PT1), which is to our knowledge the first natural molecule exerting powerful and selective inhibitory action on P2X3 receptors. PT1 dramatically slows down the removal of desensitization of these receptors. The peptide demonstrates potent antinociceptive properties in animal models of inflammatory pain.
Medical subject headings
- Pain
- Peptides
- Receptors, Purinergic P2
- Spider Venoms