Endogenous neurosteroid synthesis modulates seizure frequency.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20437568.
- Also identified by DOI 10.1002/ana.21989 and PMC identifier 2918659.
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Abstract
Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.
Medical subject headings
- Epilepsy
- Neurotransmitter Agents