Peptide antagonism as a mechanism for NK cell activation.
basic_science · Level V
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- Record sourced from PubMed, PMID 20439706.
- Also identified by DOI 10.1073/pnas.0913745107 and PMC identifier 2890497.
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Abstract
Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.
Medical subject headings
- Killer Cells, Natural