Distinct profiles of antibodies to Kaposi sarcoma-associated herpesvirus antigens in patients with Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma.
other · Level V
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- Record sourced from PubMed, PMID 20443737.
- Also identified by DOI 10.1086/652869 and PMC identifier 2873114.
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Abstract
Antibody responses against lytic and latent Kaposi sarcoma (KS)-associated herpesvirus antigens were investigated in patients with KS, multicentric Castleman disease (MCD), and primary effusion lymphoma. Antibodies against the lytic antigen K8.1 were 5-fold higher in patients with MCD than those with KS, whereas antibodies to the sum of latent antigens v-cyclin and LANA were 27-fold higher in patients with KS, compared with patients with MCD (P < 001). The sum of anti-v-cyclin and anti-LANA antibody titers discriminated patients with KS from those with MCD and KS with 93% sensitivity and 83% specificity. These results suggest that antibody responses to lytic and latent KS-associated herpesvirus antigens differ in these diseases.
Medical subject headings
- Antibodies, Viral
- Antigens, Viral
- Castleman Disease
- Herpesvirus 8, Human
- Lymphoma, Primary Effusion
- Sarcoma, Kaposi
- Virology