Speaking from the heart: systemic copper signaling.
basic_science · Level V
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- Record sourced from PubMed, PMID 20444414.
- Also identified by DOI 10.1016/j.cmet.2010.04.011.
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Abstract
Copper is a ubiquitously essential nutrient for cells. In this issue of Cell Metabolism, Kim et al. (2010) demonstrate that tissue copper status can be communicated across organ systems. In a mouse model for cardiac copper deficiency, a serum-carried signal mobilized liver and intestinal copper by inducing ATP7A, a copper-exporting ATPase.