UMA and MABP domains throw light on receptor endocytosis and selection of endosomal cargoes.

Abstract

Interactions of the ESCRT complexes are critical for endosomal trafficking. We identify two domains with potential significance for this process. The MABP domain present in metazoan ESCRT-I/MVB12 subunits, Crag, a regulator of protein sorting, and bacterial pore-forming proteins might mediate novel membrane interactions in trafficking. The UBAP1-MVB12-associated UMA domain found in MVB12 and UBAP1 defines a novel adaptor that might recruit diverse targets to ESCRT-I. Supplementary data are available at ftp://ftp.ncbi.nih.gov/pub/aravind/UMA/MVB12.html.