Cell line misidentification: the beginning of the end.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20448633.
- Also identified by DOI 10.1038/nrc2852.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cell lines are used extensively in research and drug development as models of normal and cancer tissues. However, a substantial proportion of cell lines is mislabelled or replaced by cells derived from a different individual, tissue or species. The scientific community has failed to tackle this problem and consequently thousands of misleading and potentially erroneous papers have been published using cell lines that are incorrectly identified. Recent efforts to develop a standard for the authentication of human cell lines using short tandem repeat profiling is an important step to eradicate this problem.
Medical subject headings
- Cell Line
- Gene Expression Profiling
- Microsatellite Repeats