Dysfunctional niches as a root of hematopoietic malignancy.
editorial · Level V
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- Record sourced from PubMed, PMID 20452309.
- Also identified by DOI 10.1016/j.stem.2010.04.004.
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Abstract
Whether the bone marrow microenvironment can contribute to development of blood borne cancers is controversial. In a recent issue of Nature, Raaijmakers et al. (2010) show that deletion of Dicer1 specifically in osteoprogenitors not only impaired their differentiation but also resulted in disrupted blood formation and secondary leukemia.