Thrombocytosis in adults: analysis of 777 patients.
prospective_cohort · Level II
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Abstract
A total of 777 patients with thrombocytosis, defined as a platelet count of greater than 500 x 10(9)l-1, seen in a University hospital over a 1-year period, were studied prospectively for aetiology. The most frequent causes of thrombocytosis were infection (21.9%), rebound thrombocytosis (19.4%), tissue damage (17.9%), chronic inflammatory disorders (13.1%) and malignancy (5.9%). Thrombocytosis associated with multiple causative factors, occurring simultaneously, was seen in 6.1% of cases. Thrombocytosis of greater than or equal to 1 million x 10(9)l-1 was found most frequently in patients with multiple aetiological factors occurring at the same time, in myeloproliferative disorders, or in postsplenectomy patients.
Medical subject headings
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Infections
- Infections/complications
- Inflammation
- Inflammation/complications
- Male
- Middle Aged
- Neoplasms
- Neoplasms/complications
- Platelet Count
- Prospective Studies
- Recurrence
- Surgical Procedures, Operative
- Surgical Procedures, Operative/adverse effects
- Thrombocytosis
- Thrombocytosis/blood
- Thrombocytosis/etiology