Evidence-based emergency medicine: clinical synopsis. What is the appropriate antibiotic course for the treatment of urinary tract infections in children?
systematic_review · Level I
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- Record sourced from PubMed, PMID 20471714.
- Also identified by DOI 10.1016/j.annemergmed.2010.03.034.
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Abstract
The authors searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE from 1966 to 2005, and EMBASE from 1988 to 2005, without language restriction. Randomized and quasi-randomized controlled trials comparing short-term (2 to 4 days) with standard (7 to 14 days) oral antibiotic therapy in children aged 3 months to 18 years, with culture-proven urinary tract infections. Two authors independently assessed study quality and extracted data from included trials. A random-effects model was used to analyze data. Only randomized controlled trials were included; only 2 clearly described allocation concealment, whereas none of the trials defined appropriate blinding or used an intention-to-treat analysis.