Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.
basic_science · Level V
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- Record sourced from PubMed, PMID 20473307.
- Also identified by DOI 10.1038/nm.2145 and PMC identifier 2885716.
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Abstract
A key step in gene therapy is the efficient transfer of genes in a cell type- and tissue-specific manner. To better understand the mechanism of adeno-associated virus serotype 6 (AAV6) transduction, we used comparative gene analysis (CGA) combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. Subsequent experiments suggested that EGFR is necessary for vector internalization and probably functions as a co-receptor for AAV6.
Medical subject headings
- Dependovirus
- ErbB Receptors
- Receptors, Virus