Anchoring local translation in neurons.
basic_science · Level V
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- Record sourced from PubMed, PMID 20478248.
- Also identified by DOI 10.1016/j.cell.2010.04.031 and PMC identifier 3206092.
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Abstract
In probing how protein synthesis in neurons is coupled to extracellular stimuli, Tcherkezian et al. (2010) discover that the receptor protein DCC anchors components of the translation machinery at the plasma membrane. Binding of DCC to its ligand, netrin, triggers the release of these components to initiate spatially restricted protein synthesis.