In silico design and testing of guiding tracks for molecular shuttles powered by kinesin motors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20480110.
- Also identified by DOI 10.1039/b926210e.
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Abstract
We present an extended computer simulation method which allows in silico design and testing of guiding tracks for molecular shuttles powered by kinesin motors. The simulation reproduced molecular shuttle movements under external forces and dissociation of shuttles from guiding track surfaces. The simulation was validated by comparing the simulation results with the corresponding experimental ones. Using the simulation, track designers can change guiding track designs, choose guiding methods, tune the strength of external forces, and test the module performance. This simulation would significantly reduce the effort expended in designing guiding tracks for molecular shuttles powered by kinesin motors.
Medical subject headings
- Kinesins
- Microfluidics
- Micromanipulation
- Models, Chemical
- Molecular Motor Proteins