Frequency of occult high-grade squamous intraepithelial neoplasia and invasive cancer within anal condylomata in men who have sex with men.

Schlecht, Hans P; Fugelso, Dana K; Murphy, Ryan K; Wagner, Katiri T; Doweiko, John P; Proper, Joann; Dezube, Bruce J; Panther, Lori A · Clin Infect Dis · 2010

cross_sectional · Level IV

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Abstract

Human papillomavirus causes anal condylomata, high-grade anal intraepithelial neoplasia, and anal squamous cell cancer. We found high-grade intraepithelial neoplasia or squamous cell cancer in 75 (47%) of 159 HIV-seropositive men who have sex with men (MSM) and in 42 (26%) of 160 HIV-seronegative MSM with anal condylomata meriting surgery (P<.001, determined by use of the chi(2) test). Anal condylomata in MSM often harbor high-grade intraepithelial neoplasia and squamous cell cancer.

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