Simulation of pulmonary air flow with a subject-specific boundary condition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20483412.
- Also identified by DOI 10.1016/j.jbiomech.2010.03.048 and PMC identifier 3034656.
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Abstract
We present a novel image-based technique to estimate a subject-specific boundary condition (BC) for computational fluid dynamics (CFD) simulation of pulmonary air flow. The information of regional ventilation for an individual is derived by registering two computed tomography (CT) lung datasets and then passed to the CT-resolved airways as the flow BC. The CFD simulations show that the proposed method predicts lobar volume changes consistent with direct image-measured metrics, whereas the other two traditional BCs (uniform velocity or uniform pressure) yield lobar volume changes and regional pressure differences inconsistent with observed physiology.
Medical subject headings
- Lung
- Models, Biological
- Pulmonary Ventilation