22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20485365.
- Also identified by DOI 10.1038/nrn2841 and PMC identifier 2977984.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Recent studies are beginning to paint a clear and consistent picture of the impairments in psychological and cognitive competencies that are associated with microdeletions in chromosome 22q11.2. These studies have highlighted a strong link between this genetic lesion and schizophrenia. Parallel studies in humans and animal models are starting to uncover the complex genetic and neural substrates altered by the microdeletion. In addition to offering a deeper understanding of the effects of this genetic lesion, these findings may guide analysis of other copy-number variants associated with cognitive dysfunction and psychiatric disorders.
Medical subject headings
- Brain Diseases
- Chromosome Aberrations
- Chromosome Deletion
- Chromosomes, Human, Pair 22
- Schizophrenia