Missing pieces in the Parkinson's disease puzzle.

Obeso, Jose A; Rodriguez-Oroz, Maria C; Goetz, Christopher G; Marin, Concepcion; Kordower, Jeffrey H; Rodriguez, Manuel; Hirsch, Etienne C; Farrer, Matthew et al. · Nat Med · 2010

review · Level V

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Abstract

Parkinson's disease is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology.

Medical subject headings