Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice.
basic_science · Level V
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- Record sourced from PubMed, PMID 20496900.
- Also identified by DOI 10.1021/nl101019s.
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Abstract
Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent.
Medical subject headings
- Antibodies
- CD4 Antigens
- Contrast Media
- Gold
- Lymph Nodes
- Nanoparticles
- Tomography, X-Ray Computed