Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults characterized by high viral genome load within circulating natural killer cells.

Fox, C P; Shannon-Lowe, C; Gothard, P; Kishore, B; Neilson, J; O'Connor, N; Rowe, M · Clin Infect Dis · 2010

case_series · Level IV

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Abstract

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.

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