Quantitative genetic interactions reveal biological modularity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20510918.
- Also identified by DOI 10.1016/j.cell.2010.05.019 and PMC identifier 2946632.
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Abstract
Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.
Medical subject headings
- Epistasis, Genetic
- Systems Biology