A bone to pick with compulsive behavior.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20510922.
- Also identified by DOI 10.1016/j.cell.2010.05.010.
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Abstract
Mice with mutations in the Hoxb8 gene exhibit compulsive grooming behavior. Chen et al. (2010) now report that this behavior stems from Hoxb8 deficiency in microglia, a type of immune cell in the brain derived from bone marrow. These findings provide intriguing connections between immune dysfunction and neuropsychiatric disorders.