A case report of hereditary leiomyomatosis and renal cell cancer.

Frey, Melissa K; Worley, Michael J; Heyman, Katherine P; Caputo, Thomas A · Am J Obstet Gynecol · 2010

case_report · Level V

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Abstract

A 27-year-old woman, gravida 0, presented with uterine and cutaneous leiomyomata. Genetic testing confirmed hereditary leiomyomatosis and renal cell cancer syndrome, an autosomal dominant disorder caused by germline mutations in the fumarate hydratase gene. Specific screening guidelines do not exist and are often individual and treatment center dependent.

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