Adiponectin sparks an interest in calcium.
basic_science · Level V
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- Record sourced from PubMed, PMID 20519115.
- Also identified by DOI 10.1016/j.cmet.2010.05.007.
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Abstract
Adiponectin and its receptors, AdipoR1 and AdipoR2, regulate glucose and fatty acid metabolism via activation of AMP-activated protein kinase. Recent work in Nature (Iwabu et al., 2010) demonstrates that adiponectin induces a marked Ca(2+) influx in skeletal muscle via AdipoR1 to control mitochondrial biogenesis, reduce oxidative stress, and enhance endurance capacity.