How to train your biomarker.
Level V
Where this comes from
- Record sourced from PubMed, PMID 20530694.
- Also identified by DOI 10.1158/1078-0432.CCR-10-0873.
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Abstract
Type I insulin-like growth factor (IGF) receptor (IGF1R) inhibitors are new cancer therapies. Pitts and colleagues used in vitro data to "train" a predictive biomarker for an IGF1R tyrosine kinase inhibitor. Given the complexity of IGF signaling, additional layers of biomarker analysis will likely be needed to develop predictive factors.
Medical subject headings
- Biomarkers, Tumor
- Protein Kinase Inhibitors
- Receptor, IGF Type 1