Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model.
basic_science · Level V
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- Record sourced from PubMed, PMID 20532168.
- Also identified by DOI 10.1371/journal.pone.0010943 and PMC identifier PMC6792617.
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Abstract
beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in younger individuals. We used a gamma-secretase inhibitor to lower beta-amyloid levels in young mice that model DS. This treatment corrected learning deficits characteristic of these mice, suggesting that beta-amyloid-lowering therapies might improve cognitive function in young DS patients.