Effect of nanoparticle surface charge at the plasma membrane and beyond.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20533851.
- Also identified by DOI 10.1021/nl101140t and PMC identifier 2925219.
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Abstract
Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.
Medical subject headings
- Cell Membrane
- Gold
- Metal Nanoparticles