Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20540093.
- Also identified by DOI 10.1002/jbm.a.32733 and PMC identifier 2935807.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants.
Medical subject headings
- Biocompatible Materials
- Elastomers
- Materials Testing
- Xylitol