Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer's disease.
case_control · Level III
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Abstract
Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.
Medical subject headings
- Alzheimer Disease
- Cerebral Cortex
- Physostigmine
- Tomography, Emission-Computed, Single-Photon