Preferential localization of IgG memory B cells adjacent to contracted germinal centers.
basic_science · Level V
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- Record sourced from PubMed, PMID 20547847.
- Also identified by DOI 10.1073/pnas.1005443107 and PMC identifier 2901464.
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Abstract
It has long been presumed that after leaving the germinal centers (GCs), memory B cells colonize the marginal zone or join the recirculating pool. Here we demonstrate the preferential localization of nitrophenol-chicken gamma-globulin-induced CD38(+)IgG1(+) memory B cells adjacent to contracted GCs in the spleen. The memory B cells in this region proliferated after secondary immunization, a response that was abolished by depletion of CD4(+) T cells. We also found that these IgG1(+) memory B cells could present antigen on their surface, and that this activity was required for their activation. These results implicate this peri-GC region as an important site for survival and reactivation of memory B cells.
Medical subject headings
- B-Lymphocytes
- Germinal Center
- Immunoglobulin G
- Immunologic Memory